Clinical Trials Directory

The LLDOPA study: Effect of L-DOPA on late-life depression

This study will see if L-DOPA, a drug that has been used for decades to treat Parkinson's disease, can reduce problems with mood, movement, memory, and thinking that older adults with major depression...

A long-term follow-up study of subjects with β-thalassemia or sickle cell disease treated with study product (CTX001)

A long-term follow-up study of subjects with β-thalassemia or sickle cell disease treated with Autologous CRISPR-Cas9 Modified Hematopoietic Stem Cells (CTX001).

A study to assess the pharmacokinetics, pharmacodynamics, & safety of study drug (Epeleuton) in patients with sickle cell disease

An open-label mechanistic study to assess the pharmacokinetics, pharmacodynamics, and safety of orally administered Epeleuton in patients with sickle cell disease.

A study to compare the efficacy & safety of Luspatercept vs. Epoetin Alfa for the treatment of anemia due to Myelodysplastic Syndrome in Erythropoiesis-stimulating agent-naive participants who are non-transfusion dependent

A Phase 3, open-label, randomized study to compare the efficacy and safety of Luspatercept (ACE-536) vs. Epoetin Alfa for the treatment of anemia due to revised International Prognostic Scoring System...

A study to evaluate study drug (Etavopivat) for the treatment of anemia in patients with Myelodysplastic Syndromes (MDS)

A Phase 2 open-label study to evaluate Etavopivat for the treatment of anemia in patients with Myelodysplastic Syndromes (MDS).

ASCENT – Asthma control in severe asthma patients treated with tezepelumab: a prospective, observational, real-world evidence study

This study involves primary data collection within real-world settings of participants who start treatment with tezepelumab for severe uncontrolled asthma. This study will complement evidence obtained...

ASCME Clinical Trial

The primary objective of this trial is to determine if adding high-dose lisdexamfetamine (LDX-01) (a psychostimulant) and engagement-focused CM, alone and in combination, to treatment as usual (TAU) r...

ATLAS – A randomized, double-blind, placebo controlled study assessing the long-term effect of dupilumab on prevention of lung function decline in patients with uncontrolled moderate to severe asthma

The goal of this study is to determine whether patients treated with dupilumab demonstrate prevention or slowing of lung function decline over a period of 3- years compared to standard of care therapy...

Bilateral paravertebral block for improved recovery after open heart surgery

Explore if paravertebral nerve blocks (a proven pain control method) done before open cardiac surgery, works well for improving patients quality of recovery and satisfaction.

Castleman Disease Registry & Biobank

To collect blood samples from participants with Castleman's Disease and ship these samples to the Castleman Disease Collaborative Network for research purposes.

CODEX Trial: Cognitive outcomes after Dexmedetomidine sedation in cardiac surgery patients

Explore the potential of Dexmedetomidine in preventing Postoperative Cognitive dysfunction (POCD) - A common adverse event after open cardiac surgery.

Exploring breathing difficulties following COVID-19

This study will examine what factors cause shortness of breath in individuals recovering from COVID-19, how their responses to exercise may be abnormal, and how shortness of breath and exercise capaci...

Exploring how breathing difficulties differ between men and women with COPD

This study will examine the causes of breathing difficulty in people living with chronic obstructive pulmonary disorder (COPD) and explore any differences in men versus women. This information will be...

High oxygen delivery to preserve exercise capacity in IPF patients treated with nintedanib: The HOPE-IPF Study

The purpose is to determine if patients with idiopathic pulmonary fibrosis (IPF) taking nintedanib will have improved exercise endurance, breathlessness and quality of life if breathing 60% oxygen com...

Horizon

Assessing the impact of lipoprotein(a) lowering with pelacarsen on major cardiovascular events in patients with established cardiovascular disease

KALOS – A variable length efficacy & safety study to assess an inhaled, fixed-dose, triple-combination of Budesonide/ Glycopyrronium/ Formoterol Fumarate in adults with poorly controlled asthma

This study is designed to check the safety and effectiveness of a 3 drug inhaler for people who do not have good asthma control. The study will compare two different doses of the 3 drug inhaler agains...