The LLDOPA study: Effect of L-DOPA on late-life depression

Purpose of trial

This study will see if L-DOPA, a drug that has been used for decades to treat Parkinson's disease, can reduce problems with mood, movement, memory, and thinking that older adults with major depression often experience.

Participants are people over 60 who have symptoms of major depression. In this study they are invited to take the L-DOPA challenge, where they are given doses of L-DOPA to take every day for 2 weeks. Before and after this challenge, participants answer questions about their mental health and complete assessments of their walking speed and memory and cognitive function. After the challenge, participants will receive standard treatment for depression.

In addition to examining whether L-DOPA affects participants' mood, movement, memory, and thinking, this study will also track how many participants can complete the 2-week L-DOPA challenge and what kinds of side effects they experience.

Eligibility

• Outpatient, capable of providing informed consent
• At least 60 years old
• Diagnosis of major depressive disorder
• Moderate to severe symptoms of depression
• On stable doses of psychotropic medication, including antidepressant medication, for at least 4 weeks
• Able to adhere to the study visit schedule
• Able to walk safely unassisted